Matt Iseman is a rare breed in the entertainment world—a man who traded a stethoscope for a microphone and found his true calling in comedy and television. Best known as the energetic host of American Ninja Warrior, Iseman’s journey from internal medicine to stand-up stages and primetime TV is a testament to reinvention, resilience, and the healing power of humor.
Quick Bio
| Attribute | Details |
|---|---|
| Full Name | Matthew Charles Iseman |
| Date of Birth | January 22, 1971 |
| Place of Birth | Denver, Colorado, USA |
| Nationality | American |
| Height | 6′3″ (191 cm) |
| Weight | 88 kg (194 lbs) |
| Hair Color | Dark Brown |
| Eye Color | Green/Brown |
| Occupation | Comedian, Actor, TV Host, Former Physician |
| Known For | American Ninja Warrior, Clean House, Stand-Up Comedy |
| Spouse | Britton All (m. 2024) |
Early Life and Family Background
Born on January 22, 1971, in Denver, Colorado, Matt Iseman grew up in a household steeped in medicine and academia. His father, Dr. Michael Dee Iseman, was a renowned pulmonologist, and his mother, Joan Christensen, nurtured the family with warmth and discipline. Matt was raised alongside his brother Thomas, and from an early age, he was expected to follow in his father’s footsteps. The values of hard work, compassion, and intellectual curiosity were deeply embedded in his upbringing.
Education and Medical Career
Iseman’s academic journey was nothing short of elite. He earned a Bachelor of Arts with honors from Princeton University, followed by a Doctor of Medicine from Columbia University College of Physicians and Surgeons. He completed his residency in internal medicine at the University of Colorado Hospital, returning to his hometown to serve patients. But despite his success in medicine, Matt felt a creative itch that couldn’t be ignored. The turning point came when his father told him, “Life is short, do what makes you happy.” That advice changed everything.
Transition to Comedy
In 2002, Matt Iseman made the bold decision to leave medicine and pursue comedy full-time. He joined The Groundlings, a prestigious improv troupe in Los Angeles, where he honed his comedic timing and stage presence. His routines often drew from his medical background, blending observational humor with relatable anecdotes. The transition wasn’t easy, but Matt’s unique perspective and charisma quickly set him apart in the stand-up scene.
Stand-Up and Live Performances
Iseman’s comedy style is clean, observational, and often medically inspired. He avoids off-color material, focusing instead on universal themes and clever storytelling. His performances have taken him around the globe, including USO shows in Afghanistan, South Korea, Bosnia, and Hungary, where he entertained American troops. He cites Brian Regan as a major influence, and his ability to connect with diverse audiences has made him a favorite in both comedy clubs and corporate events.
Television Hosting and Appearances
Matt’s television career began with hosting gigs on shows like Clean House, Sports Soup, Casino Night, and Scream Play. He also made guest appearances on popular series including NCIS, General Hospital, The Drew Carey Show, and Hot in Cleveland. His voice became familiar as the narrator of Dumbest Stuff on Wheels and later as the host of Live Rescue on A&E. These roles showcased his versatility and ability to balance humor with empathy.
American Ninja Warrior and Mainstream Success
In 2010, Matt Iseman joined American Ninja Warrior as the play-by-play announcer, and the show quickly became a cultural phenomenon. His energetic commentary and chemistry with co-hosts Akbar Gbaja-Biamila and Zuri Hall brought excitement and heart to the competition. Matt’s background in medicine and comedy gave him a unique lens through which to celebrate the athletes’ stories. He also hosted spin-offs like Ninja vs. Ninja and ANW Junior, further cementing his role as the face of the franchise.
Reality TV and Game Shows
In 2017, Iseman won The New Celebrity Apprentice, raising over $1 million for the Arthritis Foundation, a cause close to his heart. His victory was celebrated not just for his strategic gameplay but for his authenticity and humor. He’s also appeared on RuPaul’s Secret Celebrity Drag Race, Hollywood Game Night, 25 Words or Less, and served as a guest host on On Patrol: Live. These appearances highlight his adaptability and enduring appeal across genres.
Age and Physical Appearance
As of 2025, Matt Iseman is 54 years old. He stands tall at 6′3″ (191 cm) and maintains an athletic build that reflects his active lifestyle. With dark brown hair and green-brown eyes, Matt’s charismatic presence is as much a part of his brand as his voice. His expressive features and confident demeanor make him a natural fit for television, whether he’s hosting a high-stakes competition or cracking jokes on a game show.
Personal Life and Relationships
In September 2024, Matt married Britton All, a criminal defense attorney and fellow stand-up performer. Their relationship blossomed over shared passions and mutual respect. The proposal, which took place in Austria during a performance by Arnold Schwarzenegger, was as spontaneous and theatrical as Matt himself. Britton walked down the aisle singing “This Is Me” from The Greatest Showman, a moment that perfectly captured their dynamic. Together, they balance careers in law, comedy, and entertainment with grace and humor.
Health Journey and Advocacy
At age 31, Matt Iseman was diagnosed with rheumatoid arthritis, a chronic autoimmune condition that affects joints and mobility. He later revealed that he is also a cancer survivor, having had part of his kidney removed over a decade ago. These experiences have made him a passionate advocate for health awareness. He works closely with the Arthritis Foundation, American Cancer Society, and Cystic Fibrosis Foundation, using his platform to educate and inspire others facing similar challenges.
Philanthropy and Public Engagement
Beyond entertainment, Matt is deeply committed to philanthropy. He supports organizations like After School All Stars and the Armed Services Arts Partnership, helping underserved communities access education and creative outlets. He’s active on social media, engaging with fans and sharing updates on his work and advocacy. Whether hosting fundraisers or speaking at events, Matt uses his voice to uplift others and promote wellness.
Legacy and Cultural Impact
Matt Iseman represents a unique blend of medicine, comedy, and television—a trifecta that few have mastered. His journey from doctor to entertainer is a powerful example of following one’s passion and embracing change. He’s a role model for career reinvention, resilience, and authenticity. Through laughter, empathy, and determination, Matt continues to inspire audiences and redefine what it means to live a meaningful life.
Conclusion
From hospital halls to Hollywood stages, Matt Iseman has carved out a career that defies convention and celebrates joy. His story is one of courage, creativity, and connection. As he continues to entertain, advocate, and evolve, Matt remains a beacon of positivity in a world that could always use more laughter—and a little more heart.
FAQs
Who is Matt Iseman?
Matt Iseman is an American comedian, actor, and TV host best known for hosting American Ninja Warrior and winning The New Celebrity Apprentice in 2017.
What is Matt Iseman’s background in medicine?
He earned his M.D. from Columbia University and practiced internal medicine before switching to comedy full-time in 2002.
How old is Matt Iseman and where was he born?
Born on January 22, 1971, in Denver, Colorado, he is currently 54 years old as of 2025.
Is Matt Iseman married?
Yes, he married Britton All, a criminal defense attorney and fellow stand-up performer, in September 2024.
What health challenges has Matt Iseman faced?
He was diagnosed with rheumatoid arthritis at age 31 and is also a cancer survivor, having had part of his kidney removed.
What are Matt Iseman’s most notable TV roles?
He’s hosted Clean House, Live Rescue, Ninja vs. Ninja, 25 Words or Less, and appeared in NCIS, General Hospital, and Hot in Cleveland.
What causes does Matt Iseman support?
He actively advocates for the Arthritis Foundation, American Cancer Society, and Cystic Fibrosis Foundation.
What is Matt Iseman’s height and appearance?
He stands at 6′3″ (191 cm), has dark brown hair, green-brown eyes, and maintains an athletic build.
What is Matt Iseman’s comedy style?
His stand-up is clean, observational, and often inspired by his medical background and life experiences.
What is Matt Iseman’s legacy in entertainment?
He’s admired for blending medicine, humor, and television, inspiring others through resilience and reinvention
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